Volume 19, Issue 2 (7-2025)
payavard 2025, 19(2): 164-177 |
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Taher Jameel Alghanim N, Jadooa Abbas H, Choobineh H, Majidi Z, Dashti N. Comparative Analysis of Biochemical Parameters Across Different Stages of Kidney Disease: From Early Kidney Disease to Dialysis-Dependent Renal Failure. payavard 2025; 19 (2) :164-177
URL: http://payavard.tums.ac.ir/article-1-7932-en.html
URL: http://payavard.tums.ac.ir/article-1-7932-en.html
Nabeel Taher Jameel Alghanim1 
, Hamed Jadooa Abbas2 , Hamid Choobineh3 , Ziba Majidi4 , Nasrin Dashti *5
, Hamed Jadooa Abbas2 , Hamid Choobineh3 , Ziba Majidi4 , Nasrin Dashti *5
1- Master of Sciences Student in Clinical Biochemistry, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
2- Ph.D. in Clinical Biochemistry, Al-Faihaa General Hospital, Basrah, Iraq
3- Associate Professor, Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
4- Assistant Professor, Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
5- Associate Professor, Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran ,dashti@tums.ac.ir
2- Ph.D. in Clinical Biochemistry, Al-Faihaa General Hospital, Basrah, Iraq
3- Associate Professor, Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
4- Assistant Professor, Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
5- Associate Professor, Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran ,
Abstract: (1146 Views)
Background and Aim: This study investigated the biochemical profiles of individuals with different stages of kidney disease, including those with kidney disease without hemodialysis, chronic kidney disease without hemodialysis, and individuals with renal failure undergoing hemodialysis treatment, to clarify the role of mineral markers, inflammation, and kidney function in the complications of this disease.
Materials and Methods: This case-control study was conducted with 180 participants aged 18 to 81 years in Iraq. Participants were divided into four groups: the case group (including individuals with kidney disease not on dialysis, chronic kidney disease not on dialysis, and kidney failure treated with dialysis) and the control group, which included healthy individuals. Blood levels of urea, creatinine, calcium, phosphorus, vitamin D3, parathyroid hormone (PTH), high-sensitivity C-reactive protein (hs-CRP), and cystatin C were measured.
Results: The results showed that the levels of blood urea, calcium, vitamin D3, cystatin C and hs-CRP were significantly different between the different groups. The mean creatinine in the non-dialysis kidney disease group (3.98±1.77 mg/dL) and non-dialysis chronic kidney disease (4.59±1.63 mg/dL) was different from the dialysis kidney failure group (11.03±3.35 mg/dL) (P=0.001), but there was no significant difference between the two groups of kidney disease without dialysis and chronic kidney disease without dialysis. The phosphorus concentration was significant in all groups (P=0.001) and the highest value was observed in the dialysis kidney failure group. The PTH level was not significantly different between the two groups of non-dialysis, but there was a significant difference compared to the dialysis kidney failure group (P=0.001). Cystatin C was not significantly different in the two non-dialysis groups, but was significantly higher (P=0.001) compared with the renal failure group on dialysis (7.06±1.61 mg/dL).
Conclusion: This study demonstrated that regular monitoring of biochemical biomarkers is essential for the timely diagnosis and effective management of kidney disease. It also highlights the importance of paying attention to metabolic and inflammatory abnormalities in patients with kidney disease (especially in patients on dialysis), including extensive changes in biochemical, hormonal, and inflammatory factors levels that often occur due to severe impairment of kidney function and the dialysis process.
Materials and Methods: This case-control study was conducted with 180 participants aged 18 to 81 years in Iraq. Participants were divided into four groups: the case group (including individuals with kidney disease not on dialysis, chronic kidney disease not on dialysis, and kidney failure treated with dialysis) and the control group, which included healthy individuals. Blood levels of urea, creatinine, calcium, phosphorus, vitamin D3, parathyroid hormone (PTH), high-sensitivity C-reactive protein (hs-CRP), and cystatin C were measured.
Results: The results showed that the levels of blood urea, calcium, vitamin D3, cystatin C and hs-CRP were significantly different between the different groups. The mean creatinine in the non-dialysis kidney disease group (3.98±1.77 mg/dL) and non-dialysis chronic kidney disease (4.59±1.63 mg/dL) was different from the dialysis kidney failure group (11.03±3.35 mg/dL) (P=0.001), but there was no significant difference between the two groups of kidney disease without dialysis and chronic kidney disease without dialysis. The phosphorus concentration was significant in all groups (P=0.001) and the highest value was observed in the dialysis kidney failure group. The PTH level was not significantly different between the two groups of non-dialysis, but there was a significant difference compared to the dialysis kidney failure group (P=0.001). Cystatin C was not significantly different in the two non-dialysis groups, but was significantly higher (P=0.001) compared with the renal failure group on dialysis (7.06±1.61 mg/dL).
Conclusion: This study demonstrated that regular monitoring of biochemical biomarkers is essential for the timely diagnosis and effective management of kidney disease. It also highlights the importance of paying attention to metabolic and inflammatory abnormalities in patients with kidney disease (especially in patients on dialysis), including extensive changes in biochemical, hormonal, and inflammatory factors levels that often occur due to severe impairment of kidney function and the dialysis process.
Keywords: Hemodialysis, Chronic Kidney Disease, Vitamin D3, Calcium, Phosphorus, Parathyroid Hormone
Type of Study: Original Research |
Subject:
Laboratory Sciences
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