Volume 19, Issue 3 (9-2025)
payavard 2025, 19(3): 241-251 |
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Ethics code: IR.UMSHA.REC.1402.623
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Ataei Barazandeh Z, Imani B, Aubi E, Soltani E, Ebadian M. Comparison of the Effects of Dexmedetomidine and Fentanyl with Midazolam and Sufentanil for Anesthesia after Phacoemolsification: A Double-Blind Clinical Trial. payavard 2025; 19 (3) :241-251
URL: http://payavard.tums.ac.ir/article-1-7921-en.html
URL: http://payavard.tums.ac.ir/article-1-7921-en.html
1- Master of Sciences Student in Operating Room, Student Research Committee, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran
2- Associate Professor, Department of Operating Room, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran ,B-imani@umsha.ac.ir
3- Assistant Professor, Cancer Research Center, Institute of Cancer, Avicenna Health Research Institute, Hamadan University of Medical Sciences, Hamadan, Iran
4- Assistant Professor, Department of Ophthalmology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
5- Assistant Professor, Department of Anesthesiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2- Associate Professor, Department of Operating Room, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran ,
3- Assistant Professor, Cancer Research Center, Institute of Cancer, Avicenna Health Research Institute, Hamadan University of Medical Sciences, Hamadan, Iran
4- Assistant Professor, Department of Ophthalmology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
5- Assistant Professor, Department of Anesthesiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract: (859 Views)
Background and Aim: Cataract surgery is one of the most common eye surgeries worldwide. Most individuals undergoing this surgery are elderly patients, and the use of general anesthesia and additional medications can lead to complications during and after the surgery, as well as increased costs for patients. Therefore, the present study aimed to investigate the effects of intravenous Dexmedetomidine and Fentanyl, as well as Midazolam and intravenous Sufentanil, on pain intensity, hemodynamic status, surgeon satisfaction, and the level of sedation in patients undergoing cataract surgery.
Materials and Methods: This double-blind clinical trial was conducted on 80 patients who were candidates for cataract surgery at Farshchian Sina Hospital in Hamadan. Sampling was carried out from March 10, 2023 to August 21, 2024. The intervention group received Dexmedetomidine and intravenous fentanyl, while the control group received midazolam and Sufentanil. Blood pressure, heart rate, and oxygen saturation level, were measured. Pain intensity, surgeon satisfaction, and the level of sedation in patients were measured and recorded. The results of the research utilized qualitative and quantitative variables based on the study groups, using counts (percentages) and means (standard deviations). For the statistical analysis of these variables at baseline, chi-square tests and independent t-tests were employed. To assess the impact of treatment groups on pain throughout the study, repeated measures ANOVA was used, and the interaction between time and group was evaluated. In cases where the outcome variable under study was not normally distributed, non-parametric equivalents such as the Mann-Whitney test were applied. A significance level of P-Value<0.05 was considered. All statistical tests were conducted using Stata software.
Results: In the intervention group, heart rate and blood pressure decreased over time. Changes in heart rate and blood pressure had no effect on the patients’ recovery process. Oxygen saturation level in the intervention group did not change compared to the control group over time. The medication used in the intervention group did not cause shortness of breath or a decrease in oxygen saturation levels. Additionally, there was no significant difference in pain levels between the two groups. The level of sedation in patients and surgeon satisfaction in the intervention group was higher than the control group.
Conclusion: Based on the results of the research, it is recommended to use Dexmedetomidine in cataract surgery and other surgeries that require sedation.
Materials and Methods: This double-blind clinical trial was conducted on 80 patients who were candidates for cataract surgery at Farshchian Sina Hospital in Hamadan. Sampling was carried out from March 10, 2023 to August 21, 2024. The intervention group received Dexmedetomidine and intravenous fentanyl, while the control group received midazolam and Sufentanil. Blood pressure, heart rate, and oxygen saturation level, were measured. Pain intensity, surgeon satisfaction, and the level of sedation in patients were measured and recorded. The results of the research utilized qualitative and quantitative variables based on the study groups, using counts (percentages) and means (standard deviations). For the statistical analysis of these variables at baseline, chi-square tests and independent t-tests were employed. To assess the impact of treatment groups on pain throughout the study, repeated measures ANOVA was used, and the interaction between time and group was evaluated. In cases where the outcome variable under study was not normally distributed, non-parametric equivalents such as the Mann-Whitney test were applied. A significance level of P-Value<0.05 was considered. All statistical tests were conducted using Stata software.
Results: In the intervention group, heart rate and blood pressure decreased over time. Changes in heart rate and blood pressure had no effect on the patients’ recovery process. Oxygen saturation level in the intervention group did not change compared to the control group over time. The medication used in the intervention group did not cause shortness of breath or a decrease in oxygen saturation levels. Additionally, there was no significant difference in pain levels between the two groups. The level of sedation in patients and surgeon satisfaction in the intervention group was higher than the control group.
Conclusion: Based on the results of the research, it is recommended to use Dexmedetomidine in cataract surgery and other surgeries that require sedation.
Type of Study: Original Research |
Subject:
Surgery Room
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