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Assessment of lactoferrin concentration in human milk and survey on it's relation with age, childbirth time, and after childbirth
Ar Salehinodeh, Mb Eslami, M Noruzi, S Nasirinejad, M Fazli, Gr Hassan Pour,
Volume 2, Issue 4 (29 2009)
Abstract

Background and Aim : Lactoferrin is one of the milk components with the main role in iron absorption and transfer. As a result of this action the pathogens that need iron for their life cannot grow, so the infection will be controled, indirectly. Moreover, because the lactoferrin production is stopped in the women with breast cancer, evaluation of this protein in milk may be the first step in detection of breast cancer tumors, and making decision about the appropriate treatment methods. Therefore, with due attention to the important role of lactoferrin in health and disease, determination of its normal dose in milk is very essential for the differences that may occur comparing with the normal situation. Also since the normal amount of lactoferrin in the milk of Iranian women was not evaluated in this study the amount of protein in more than 100 sample was measured.

Materias and Methods: The lactoferrin amount was measured by SRID method in 104 human milk samples of mothers that were referred to two public health centers in Tehran for vaccination of their children, and also in women that were hospitalized after childbirth in 2 health centers of Qom city. The data such as age, time of childbirth, etc were obtained by asking them and filling pre-designed questionnaire. All laboratory experiments were conducted in the Immunology unit of pathobiology department of School of Public Health, Tehran University of Medical Sciences.

Results: The mean concentration of lactoferrin was 4.39 g/L, in the early milk (6-10 days after childbirth) was 3.79 g/L and in the mature milk (11-60 days after childbirth) measured as 2.45 g/L.

Discussion and Conclusion: The mean concentration of Lactoferrin in milk (g/L) has a significant difference with the day after childbirth (P<0.05) and was highest in Colostrums and then in primary milk. After that this amount is reduced extremely. This indicates the important role of lactoferrin in the primary days of infants, because of the protective role that it has against infections. Also the results of this study showed no significant correlation between human milk and factors such as age and childbirth time.


Assessment Of Urban Family Physician Program In Pilot Centers Covered By Ahvaz Jundishapur University Of Medical Sciences
Shahrokh Reiesian, Maryam Eslamian, Mohammad Azmal , Peivand Bastani , Rohollah Kalhor,
Volume 7, Issue 1 (5-2013)
Abstract

  Background and Aim: Family physician is the core in the world efforts for quality improvement, cost effectiveness, and equity in the health care systems. The main purpose of this present study was to investigate situation of the family physician program and identify referral route in this program in six pilot cities in Khuzestan province .

  Materials and Methods: A cross-sectional descriptive study was conducted in 2011. Pre-designed checklists were used for collecting data. In this study, 15 healthcare team in six pilot cities for family physician program in Khuzestan province were examined and their specified referral levels for each city was investigated and compared with the national instruction to identify current gaps.

  Results: The least number of staff belonged to nutrition, nurses and physicions respectively. In the second referral level cities, Specialists did not welcome the program . In Mahshar, a second level city, five specialists have been registered to family physician program. In the third level, 28/5 percent of specialist were enrolled in this program.

  Conclusion : It seems that it is necessary to facilitate patient access to physicians under contract with family physician program and referral system in second and third levels. Therefore, establishing a motivation system for attracting specialist and improving their maintenance situation can also be beneficial.

 


Estimation of the Production Function of Ahvaz University of Medical Sciences Hospitals during 2006-2014
Safiyeh Yaghoubi, Reza Goudarzi, Mostafa Baniasadi , Maryam Eslamiyan, Noorolhoda Fakhrzad , Mohsen Barouni,
Volume 11, Issue 2 (7-2017)
Abstract
Background and Aim:  Hospital as an economic entity, should utilize economic analysis for the optimal use of resources and production facilities. The aim of this study was to estimate the production function of Ahvaz University of Medical Sciences during the period 2006-2014.
Materials and Methods: This study was a descriptive cross-sectional analysis. The Data were collected during a period of 9 years in 7 hospitals in Ahvaz. The dependent variable in this study was the number of hospital admissions as the production level and the explanatory variables, including nurses, physicians, staffs, and the number of beds. To determine and specify the form of subordinated Cobb - Douglas production function was used. Data analysis and econometric model was estimated using STATA11. 
Results: Research findings showed 0.28 elasticity for the physicians, elasticity for  nurses, number of beds , outpatient reception and other staffs were 0.10, 0.95, 0.30 and -0.11 respectively. In other words, the most production in these hospitals was dependent on the number of beds. It was an economic activity that consumed a lot of capital. The sum of the coefficients of the production function was 0.88 and the return to the scale was downward.
Conclusion: The findings of this study showed that hospital beds have great importance in increasing production. Therefore, the rate of active bed occupancy in these hospitals is high and has the largest role in the production of hospitals or the number of inpatient discharge. 

The Impact of Knowledge Management on the Innovation Performance in the Pharmaceutical Industry (Case Study: R & D Department Staff of Salamat Pharmaceutical Investment Holding)
Leila Eslami Eshlaghi, Abbas Khamseh,
Volume 13, Issue 1 (Apr & May 2019)
Abstract
Background and Aim: The present study was conducted to investigate the effect of knowledge management on innovation performance in the pharmaceutical industry, which leads to a sustainable competitive advantage. The purpose of this study was to determine the effect of knowledge management on innovation performance in Salamat pharmaceutical investment holding.   
Materials and Methods: This study is a descriptive-survey applied in terms of data collection method, The statistical population of this research included all the experts and managers of the Salamat Holding Research and Development Unit located in Tehran in the first half of the year 2018. Data were collected through a census, and tools used in this study consisted of standard questionnaire of innovation performance, knowledge management and dynamic capabilities of knowledge management. Data analysis was done by using SPSS and SMART PLS software.         
Results: The results indicate that R & D, product innovation, process innovation and organization size have a significant correlation with innovation performance, which with R2=0.98 have been able to predict the behavior of the variable of innovation performance. R & D with ß=0.466 has the most positive impact on innovation performance. But the hypothesis about the significant effect of knowledge management on innovation performance and, consequently, the moderating effect of KMdynamic capabilities on knowledge management relationships on innovation performance was not valid.
Conclusion: Considering the results of this study, Thinking about the transformation of traditional business methods into new forms and the provision of a behavioral and cultural context in the implementation of knowledge management is significant.             

Survey on the Contamination Rate of Stagnant Water and Soil to Vermamoeba vermiformis in Arak Parks, Iran, 2017-2018
Hamideh Sadat Atyabi, Sima Rasti, Maryam Niyyati, Zahra Eslamirad, Mahdi Delavari, Gholam Abbass Moosavi,
Volume 13, Issue 3 (Aug & Sep 2019)
Abstract
Background and Aim: Vermamoeba vermiformis is an opportunistic free living amoeba(FLA) that is ubiquitous in different environmental sources. This Amoeba can cause Amoebic Keratitis(AK) and Granulomatous Amoebic Encephlitis (GAE) in immunocompromised patients. This study was conducted to determine the rate of Vermamoeba vermiformis in stagnant water and soil in Arak.
Materials and Methods:  In this Cross-Sectional study, stagnant water(60) and soil samples(36) were collected from Arak parks. The samples were filtered in 0.45µm nitrocellulose paper and cultured on to 1.5% NNA for the presence of free living amoeba(FLA). After DNA extraction, Vermamoeba vermiformis was identified by Polymerase Chain Reaction(PCR) using primers NA1 and NA2. Eight isolates of Vermamoeba vermiformis were sequenced blasted and after confirmation, recorded in the Gene Bank. The data were recorded in SPSS.16 and analyzed using X2 and Fischer Exact test.
Results: Out of 96 environmental sources, 29.2% were positive for free living amoeba. The rate of FLA pollution in stagnant water and soil were 28.3 and 30.6% respectively(P<0.001). The contamination rate of stagnant water and soil with Vermamoeba vermiformis were 10% and 16.7%, respectively(P<0.001).
Conclusion: The results of the present study revealed ,that stagnant water and soil resources were contaminated to FLA and Vermamoeba. Due to the Pathogenic ability of this amoeba and the possibility of endosymbian pathogens in it, health education is recommended for controlling and preventing the disease, especially in susceptible patients, including those who use contact lenses.

A Survey of Medical Students’ Views of Tehran University of Medical Sciences about Clerkship Programs during the Covid-19
Miss Maryam Eslami, Javad Jahangirzadeh,
Volume 16, Issue 6 (Feb 2023)
Abstract
Background and Aim: The curriculum as the heart of the educational system is one of the effective factors in achieving the goals and mission of the university and its evaluation is of particular importance. Since medical education deals with human life and clerkships also play an essential role in shaping the professional abilities of medical students, this research was conducted with the aim of determining the desirability of clerkship programs from the point of view of medical students of Tehran University of Medical Sciences during the Covid-19 pandemic based on the nine elements of Francis Klein.
Materials and Methods: In this study, a descriptive-survey method was used. The statistical population was 487 medical students of Tehran University of Medical Sciences, who were undergoing the clerkship stage at the time of the research, and the questionnaire was provided to them in the form of a census. The number of samples was determined based on Morgan’s table of 215 people. The research tool was a standard questionnaire, the validity of which was confirmed by professors in the field of educational sciences, and its reliability was calculated using the Cronbach’s alpha method of 0.794. Descriptive statistics (including statistical tables, graphs, central and dispersion indices) and inferential statistics (including one-sample t-tests and independent two-sample t-tests) were used for data analysis.
Results: The results showed that clerkship programs from the point of view of medical students of Tehran University of Medical Sciences during the covid-19 disease, considering that the t-statistic of all research variables is less than 1.96 (educational objectives t=-4.735, educational content t=0/666, learning activities t=-7.812, teaching strategies t=-4.246, educational materials and resources t=-0.970, grouping of learners t=-5.223, learning space (place) t=-4.029, learning time t=-5.043, and learning evaluation t=-7.348) were not desirable in terms of all elements. It was also found that there is no significant difference in attitudes between male and female students regarding the desirability of these programs except for the element of educational goals.
Conclusion: According to the results of the research, the medical clerkship programs of Tehran University of Medical Sciences are facing challenges during the Covid-19 pandemic. Therefore, it is necessary to provide a program that is compatible with the conditions and can meet the educational needs of the learners.

The Effect of D-Peptide-B and B.Bifidum Probiotic Lysate on the Expression of TNF-α and IL-1 Genes in AGS Cancer Cell Line Compared to Healthy HEK Cells
Shima Derakhshan, Negar Yavari Tehrani Fard, Nahid Abotalbe, Maryam Naseroleslami,
Volume 17, Issue 2 (5-2023)
Abstract
Background and Aim: Today, natural compounds such as peptides and probiotics can be mentioned as a supplement to the treatment of diseases such as cancer. These compounds may be effective in preventing the progression or treatment of cancer by affecting some molecular pathways including inflammation. The aim of this study was to investigate the effect of D-peptide-B and B.bifidum probiotic lysate on the expression of TNF-α and IL-1 genes in gastric cancer cells of AGS cell line.
Materials and Methods: In this study, AGS and HEK cells were cultured in DMEM medium with 10% bovine serum. The cells were treated with different concentrations of D-peptide-B and B.bifidum lysate and were incubated for 24 hours. The cell viability was checked by MTT. For molecular investigations, after RNA extraction and cDNA synthesis, the relative expression of TNF-α and IL-1 genes was evaluated using Real time PCR, and the data were analyzed using statistical methods One-way ANOVA.
Results: The MTT results indicated that the AGS cancer cells’ survival rate decreased after treatment with dipeptide-B and lysate of B.bifidum as compared to HEK control cells. Furthermore, the study found that the expression levels of TNF-α and IL-1 genes in gastric cancer cells were significantly higher after treatment with D-Peptide-B, bacterial lysate, or both, when compared to normal HEK cells (P≤0.05). Specifically, the IL-1 gene expression increased by 300% (4 times) for peptide treatment, 100% (2 times) for bacterial treatment, and 650% (7.5 times) for combined treatment. Similarly, the TNF-α gene expression increased by 350% for peptide treatment, 100% for bacterial treatment, and 520% for combined treatment. These results suggest that these compounds may have induced cell death in cancer cells by affecting other molecular pathways.
Conclusion: Considering that D-peptide-B and B.bifidum lysate had no significant toxicity on normal cells and caused a significant decrease in the survival of cancer cells and this toxicity was dose dependent, therefore, consideration might be given to these natural compounds in treatment of gastric cancer.

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