Volume 11, Issue 5 (1-2018)
payavard 2018, 11(5): 560-566 |
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Soltan Dallal M M, Nikmanesh B, Haghi-Ashtiani M T, Okazi A, Sharifi Yazdi M K. Serotyping and Multiple Antibiotic Resistance Patterns of Shigella Sonnei Isolated from Diarrhea in Children’s Medical Center of Tehran. payavard 2018; 11 (5) :560-566
URL: http://payavard.tums.ac.ir/article-1-6398-en.html
URL: http://payavard.tums.ac.ir/article-1-6398-en.html
Mohammad Mehdi Soltan Dallal * 
1, Bahram Nikmanesh2 , Mohammad Taghi Haghi-Ashtiani3 , Arash Okazi4 , Mohammad Kazem Sharifi Yazdi5
1, Bahram Nikmanesh2 , Mohammad Taghi Haghi-Ashtiani3 , Arash Okazi4 , Mohammad Kazem Sharifi Yazdi5
1- Professor, Food Microbiology Department, School of Public Health, Food Microbiology Research Center, Tehran University of Medical Sciences,Tehran, Iran , soltanda@tums.ac.ir
2- Assistant Professor, Medical Laboratory Sciences Department, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
3- Professor, Pathology Department, School of Medicine, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
4- Assistant Professor, Forensic Medicine Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5- Professor, Medical Laboratory Sciences Department, School of Allied Medical Sciences, Zoonosis Research Centre, Tehran University of Medical Sciences, Tehran, Iran
2- Assistant Professor, Medical Laboratory Sciences Department, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
3- Professor, Pathology Department, School of Medicine, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
4- Assistant Professor, Forensic Medicine Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5- Professor, Medical Laboratory Sciences Department, School of Allied Medical Sciences, Zoonosis Research Centre, Tehran University of Medical Sciences, Tehran, Iran
Abstract: (4362 Views)
Background and Aim: In today’s world, antibiotic resistance is inevitable. This has been the case since the discovery of antibiotics. The aim of this research is to study serotyping and multiple antibiotic resistance pattern of Shigella sonnei isolated from diarrheal stool of patients hospitalized in Children’s Medical Center in Tehran.
Materials and Methods: In this descriptive study, 600 diarrheal stool specimens were obtained from patients hospitalized in Children’s Medical Center in Tehran over a period of twelve months. The stool samples were collected in Cary-Blair transport medium and transferred to the laboratory. The identification was carried out according to the standard cultivation method, and the antibiotic susceptibility test was performed by Kerry Bauer disk method according to with CLSI procedure.
Results: Out of 600 samples, only 18 (3%) were found to be contaminated with Shigella sonnei. The results of antibiotic resistance patterns of these isolates showed that they were resistant to tetracycline; streptomycin, clindamycin and cortimoxazol. Furthermore, 66.67% of isolates had multiple resistance to tetracycline, cortimoxazol, streptomycin, ticarcillin and clindamycin antibiotics.
Conclusion: The results of this study showed that multiple resistance of Shigella sonnei to tested antibiotics is increasing. This is alarming; necessary steps should be taken to prevent such a phenomenon.
Materials and Methods: In this descriptive study, 600 diarrheal stool specimens were obtained from patients hospitalized in Children’s Medical Center in Tehran over a period of twelve months. The stool samples were collected in Cary-Blair transport medium and transferred to the laboratory. The identification was carried out according to the standard cultivation method, and the antibiotic susceptibility test was performed by Kerry Bauer disk method according to with CLSI procedure.
Results: Out of 600 samples, only 18 (3%) were found to be contaminated with Shigella sonnei. The results of antibiotic resistance patterns of these isolates showed that they were resistant to tetracycline; streptomycin, clindamycin and cortimoxazol. Furthermore, 66.67% of isolates had multiple resistance to tetracycline, cortimoxazol, streptomycin, ticarcillin and clindamycin antibiotics.
Conclusion: The results of this study showed that multiple resistance of Shigella sonnei to tested antibiotics is increasing. This is alarming; necessary steps should be taken to prevent such a phenomenon.
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