Volume 4, Number 3 and 4 (20 2011)                   payavard 2011, 4(3 and 4): 28-35 | Back to browse issues page


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Nabatchian F, Einollahi N, Dashti N, Sarrafnejad A, Vatani G. Prooxidant - Antioxidant Balance In CAD Patients. payavard. 2011; 4 (3 and 4) :28-35
URL: http://payavard.tums.ac.ir/article-1-91-en.html

Abstract:   (4543 Views)

Background and Aim: The balance between ROS generation and antioxidant activity is critical to the pathogenesis of oxidative stress related disorders. In this study the prooxidant - antioxidant balance and its correlation with lipid profile and uric acid was determined to evaluate the PAB as a prognostic factor for CAD.

Materials and Methods: Seventy - two patients and sixty eight healthy volunteers were enrolled in this study. The values of PAB were determined by using standard solutions and ELISA method.
Triglyceride, total cholesterol, LDL- cholesterol, HDL - cholesterol and uric acid were measured by enzymatic method.

Results: The PAB values of CAD patients and control group were 70.01±3.36 (HK unit) and 66.40 ± 2.84 (HK unit) respectively. There was no significant difference between PAB values among the two groups (P= 0.41). There was no significant difference between uric acid levels among the two groups (P= 0.46). There was a significant correlation between the uric acid values among patients and healthy volunteers and PAB values (P <0.01). There was a significant correlation between the TG, values among patients and healthy volunteers and PAB values (P<0.05).

Conclusion: This study showed oxidative stress could be used as a significant risk predictor in the coronary artery disease patient

Full-Text [PDF 426 kb]   (1433 Downloads)    
Type of Study: Research | Subject: Hospital Managment
Received: 2010/07/20 | Accepted: 2010/09/24 | Published: 2013/07/29

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