Volume 12, Issue 4 (Oct & Nov 2018)                   payavard 2018, 12(4): 249-259 | Back to browse issues page

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Orooji A, Langarizadeh M, Aghazadeh M, Kamkarhaghighi M, Ghazisaiedi M, Moghbeli F. Dosing of Warfarin in Iranian Adult Patients with An Artificial Heart Valve Using Artificial Neural Networks. payavard. 2018; 12 (4) :249-259
URL: http://payavard.tums.ac.ir/article-1-6567-en.html
1- PhD candidate in Medical Informatics, Health Information Management Department, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran.
2- Assistant Professor, Health Information Management Department, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran , Langarizadeh.m@iums.ac.ir
3- Master of Sciense in Medical Informatics, Health Information Management Department, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
4- Ph.D. Candidate in Electrical and Computer Engineering, Department of Computer, University of Ontario Institute of Technology (UOIT), Ontario, Canada
5- Associate Professor,Health Information Management Department, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
6- PhD candidate in medical informatics, Health Information Management Department, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran.
Abstract:   (395 Views)
Background and Aim: Artificial intelligence is a branch of computer science that has the ability of analyzing complex medical data. Using artificial intelligence is common in diagnosing, treating and taking care of patients. Warfarin is one of the most commonly prescribed oral anticoagulants. Determining the exact dose of warfarin needed for patients is one of the major challenges in the health system, which has attracted the attention of researchers. The purpose of this study was to determine the exact dose of warfarin needed for patients with artificial heart valves using artificial neural networks (ANN).
Materials and Methods: A total of 9 multi-layer perceptron ANNs with different structures were constructed and evaluated based on a dataset including 846 patients who had referred to the PT clinic in Tehran Heart Center in the second half of the year 2013. Finally, the best structure of ANN for warfarin dose was investigated. All simulations including data preprocessing and neural network designing were done in MATLAB environment.
Results: The effectiveness of ANNs was evaluated in terms of classification performance using 10-fold cross-validation procedure and the results showed that the best model was a network that had 7 neurons in its hidden layer with an average absolute error of 0.1, turbulence rate of 0.33, and regression of 0.87. 
Conclusion: The achieved results reveal that ANNs are able to predict warfarin dose in Iranian patients with an artificial heart valve. Although no system can be guaranteed to achieve 100% accuracy, they can be effective in reducing medical errors.

Full-Text [PDF 644 kb]   (53 Downloads)    
Type of Study: Research | Subject: Health Information Technology
ePublished: 2018/10/16

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