Volume 10, Number 2 (5-2016)                   payavard 2016, 10(2): 119-132 | Back to browse issues page


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Nabatchian F, Ashteeani M, Noroozi A. The Effect of Combined Vitamin Supplements Compared with Single Vitamins D3, A, E in Reducing Oxidative Stress in Female Mice with Breast Cancer. payavard. 2016; 10 (2) :119-132
URL: http://payavard.tums.ac.ir/article-1-6043-en.html

1- Associate Professor, Medical Laboratory Sciences Department, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran Associate Professor, Medical Laboratory Sciences Department, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran , nabatchi@sina.tums.ac.ir
2- Master of Science Student in Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Master of Science Student in Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan
3- Bachelor of Science in Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran Bachelor of Science in Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran
Abstract:   (2690 Views)

Background and Aim: Breast cancer is epidemiological and most important cause of death in women. Oxidative stress plays an important role in this disease. Antioxidants such as some vitamins has attracted the attention of scientists to deal with oxidative stress. The aim of this study was to determine the effect of vitamin supplements in reducing oxidative stress in breast cancer.

Materials and Methods: 38 BALB-C mice were used. They were created in the breast cancer by cell implantation procedure. Rats were divided into 4 groups: 4 mice were given vitamin supplements for 1 month, 4 mice vitamin A, 4 mice, vitamin D, and 4 mice were given vitamin E respectively. After a month mice had breast cancer. In the second group mice without vitamin supplements, were affected. In the third group, mice with vitamin supplements were not affected. In the blood serum of rats, the catalase, superoxide dismutase and total antioxidant capacity was measured by ELISA.

Results: Catalase activity in mice that received vitamin supplements was significantly increased and were diagnosed (P=0.049). But the increase was not significant with vitamin D supplement (P=0.287). Superoxide dismutase in mice that received vitamin supplements and were free of disease increased significantly (P=0.0249). But the increase was not statistically significant with vitamin D supplement (P=0.24).The total antioxidant capacity in mice that received vitamin supplements and were affected with breast cancer was significantly increased (P<0.0001). This increase was not significant with vitamin D (P=0.006).

Conclusion: The use of vitamin supplements with catalase, superoxide dismutase and total antioxidant capacity was significantly correlated and may increase the level of antioxidant markers.

Full-Text [PDF 1278 kb]   (545 Downloads)    
Type of Study: Research | Subject: Laboratory Sciences
Received: 2016/11/23 | Accepted: 2016/11/23 | Published: 2016/11/23

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