Volume 9, Number 5 (2-2016)                   payavard 2016, 9(5): 469-477 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Heidarpourian S, Shahidi M, Kazemi A, Razavi M, Basi A, Hayat P. Study Of Relationship Between Circulating Endothelial Cell Numbers And Plasma VWF Levels With Other Hematologic Findings In Patient With Chronic Lymphocytic Leukemia. payavard. 2016; 9 (5) :469-477
URL: http://payavard.tums.ac.ir/article-1-5882-en.html

1- Master of Science in Hematology & Blood Banking, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
2- Assistant Professor, Hematology & Blood Banking Department, School of Allied Medicine, Cellular & Molecular Research Center (CMRC), Iran University of Medical Sciences, Tehran, Iran , shahidi.m@iums.ac.ir
3- Professor, Hematology & Blood Banking Department, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
4- Associate Professor, Hematology-Oncology Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
5- Bachelor of Science in Biology, Cellular & Molecular Research Center (CMRC), Iran University of Medical Sciences, Tehran, Iran
Abstract:   (1596 Views)

Background and Aim: Chronic lymphocytic leukemia (CLL) is a lymphoprolifrative disorder, which is very heterogeneous in prognosis. Therefore, the analysis of the prognostic factors should be very helpful in diagnosing patients with a poor prognosis. The aim of this study was to determine the relationship between circulating Endothelial cells number with VWF levels along with the other hematological findings in CLL.

Materials and Methods: Peripheral blood samples were obtained from 30 CLL patients admitted to the hematology department of Firozgar hospital and 30 healthy subjects. The levels of CEC were measured by the presence of CD34 and VWF markers, and absence of CD45 marker, using flow cytometry. VWF levels was evaluated by ELISA.

Results: The CEC levels were significantly higher in blood of the CLL patients (0.64%), when compared to the controls (0.12%, P=0.002). The levels of plasma VWF were higher among high grade patients, when compared to controls and patients in lower grades. There was a negative correlation between CEC levels, and Hb concentration in the patients group (r=-0.47, P=0.01).

Conclusion: Although the levels of both CEC count and plasma VWF in patient with high grade CLL were increased when compared to patients with low grade, there was no significant correlation between these two parameters.

Full-Text [PDF 1023 kb]   (650 Downloads)    
Type of Study: Research | Subject: Hospital Managment
Received: 2016/02/29 | Accepted: 2016/02/29 | Published: 2016/02/29

Add your comments about this article : Your username or email:
Write the security code in the box

Send email to the article author


© 2015 All Rights Reserved | Journal of Payavard Salamat

Designed & Developed by : Yektaweb